Oprah joins wave of celebrities who revealed dramatic weight loss in 2025

Celebrities person been striving for wellness successful 2025, pinch galore dropping important amounts of weight — successful galore cases pinch nan thief of GLP-1 medications for illustration Ozempic.

Below are 4 A-list stars who shared their weight-loss journeys this year, pinch aliases without nan thief of medicine drugs.

No. 1: Oprah Winfrey

Long-time talk show big Oprah Winfrey was precocious featured successful an exclusive question and reply pinch People Magazine, during which she discussed her weight nonaccomplishment and her caller book, "Enough: Your Health, Your Weight and What It’s Like to Be Free."

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Winfrey, 71, began taking a GLP-1 medication successful 2023 but attempted to discontinue conscionable six months successful to spot if she could suffer weight without it. Regardless of her fare and workout routines, nan media mogul said she still gained backmost 20 pounds aft stopping nan drug.

Oprah Winfrey is pictured successful February 2020 (left) and successful October 2025 (right). (Steve Jennings/Getty Images; Lanna Apisukh/WWD via Getty Images)

"It's going to beryllium a life thing," she shared. "I'm connected precocious humor unit medication, and if I spell disconnected nan high humor pressure medication, my humor unit is going to spell up. The aforesaid point is existent now, I realize, pinch these medications. I’ve proven to myself [that] I request it."

Winfrey revealed that her default weight, astatine 211 pounds, was not healthy, arsenic she was pre-diabetic and had precocious cholesterol.

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The writer told People that she injects a GLP-1 weekly, and has besides paid retired of pouch for friends who could not spend nan drug.

Winfrey added that nan absence of nutrient sound "has fixed maine a quiet spot that comes pinch everything I do. Everything is conscionable calmer and stronger."

Amy Schumer, Meghan Trainor and Oprah Winfrey (left to right) are among nan celebrities who person revealed their weight nonaccomplishment successful 2025. (Raymond Hall/GC Images; Chris Haston/WBTV via Getty Images; Theo Wargo/Getty Images)

Regardless of GLP-1 entree aliases tolerance, Winfrey encouraged those struggling pinch obesity that it is "not your fault."

"I want group to extremity blaming [themselves] for genes and an situation [they] can’t control," she said. "I want group to person nan information, immoderate you take to do pinch it, whether you get nan medications, aliases whether you want to support dieting."

No. 2: Amy Schumer

Comedian Amy Schumer dropped 50 pounds aft being diagnosed pinch Cushing’s syndrome, a hormonal upset that tin origin utmost swelling, fatigue and perchance fatal complications.

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Schumer's translator sparked speech online, to which she responded successful a now-deleted Instagram station that unopen down speculation astir cosmetic enhancements.

"I didn’t suffer 30 lbs — I mislaid 50," she emphasized connected societal media, adding that she does not get Botox aliases filler.

Amy Schumer is pictured successful May 2024 astatine left, and connected nan correct aft her weight nonaccomplishment successful 2025. (Marleen Moise/WireImage; Amy Schumer/Instagram)

Schumer doubled down that her weight nonaccomplishment was not astir her appearance, but astir staying alive. She besides confirmed that she has utilized nan GLP-1 medicine Mounjaro.

"Not to look hot, which does consciousness nosy and temporary," she said. "I did it to survive. I had a illness that makes your look highly puffy that tin termination you, but nan net caught it and that illness has cleared."

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"Sorry for immoderate emotion it’s giving you that I mislaid that weight," she added. "I’ve had plastic surgery complete nan years and I usage [Mounjaro] … I’m pain-free. I tin [play] tag pinch my son."

The character besides addressed her shifting hormones, saying that she’s "happy to stock much if anyone has immoderate questions astir really I’m looking aliases emotion aliases wherever I americium successful my perimenopause process."

No. 3: Meghan Trainor

"All About That Bass" vocalist Meghan Trainor has besides confronted haters for "body-shaming" her aft a melodramatic 60-pound weight loss.

MEGHAN TRAINOR BLASTS BODY SHAMERS WHO ‘ATTACK’ HER AFTER 60-POUND WEIGHT LOSS

Trainor precocious told "Entertainment Tonight" that she’s "never felt better" and is taking attraction of her health for nan first clip since having her 2 children.

Meghan Trainor showed disconnected her melodramatic weight nonaccomplishment astatine nan Baby2Baby Gala successful November 2025.  (Emma McIntyre/Getty Images for SiriusXM; Michael Kovac/Getty Images for Baby2Baby)

"I consciousness great, and that’s erstwhile group onslaught me," she said, noting that nan disapproval is only getting "louder" and "meaner." Despite nan online noise, Trainor emphasized that she’s focused connected her well-being.

"I’m taking attraction of myself," she reiterated. "I person to find a measurement to not beryllium affected by that."

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The singer's wellness travel began by eliminating gluten and dairy from her fare aft uncovering retired that she had a "leaky gut." The creator besides sewage superior astir strength training.

Trainor’s ain fittingness trainer, Bella Maher of Malibu Bodies, posted before-and-after photos of nan popular prima connected Instagram, revealing really difficult she worked earlier introducing a GLP-1 drug.

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"Watching her toggle shape from nan wrong retired has been 1 of nan astir meaningful parts of my work," nan caption reads. "She did truthful overmuch of this connected her ain earlier ever introducing a GLP-1, and moreover aft starting it, nan medicine was simply a support, not nan logic for her results. GLP-1s tin beryllium a powerful tool, but they’re surely not a translator plan. SHE is nan logic this worked."

No. 4: Lizzo

Singer and musician Lizzo stepped retired this twelvemonth pinch a slimmer figure, arsenic nan nationalist speculated astir her GLP-1 use.

During a chat astir Ozempic connected Trisha Paytas’ "Just Trish" podcast successful June, nan musician shared that she had "tried everything" for weight loss.

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"Ozempic useful because you eat little food," she said. "It makes you consciousness full. So, if you tin conscionable do that connected your ain and get mind complete matter, it's nan same."

Lizzo is pictured successful March 2021 (left) and successful March 2025 (right). (Jay L. Clendenin/Los Angeles Times via Getty Images; Karwai Tang/WireImage)

Lizzo shared that ending her vegan fare and eating much nutrient helped her instrumentality to a caloric deficit, since she erstwhile consumed "a batch of clone meat," breadstuff and rice.

"And I had to eat a batch of it to enactment afloat … I was consuming 3,000 to 5,000 calories a day."

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"For me, erstwhile I started eating full foods, for illustration beef and chickenhearted and fish, I was really afloat and not expanding my tummy by putting a batch of … clone things successful location that weren't really filling maine up," she added.

The Grammy victor revealed that her biggest inspiration for losing weight was to alleviate nan intense backmost pain she would consciousness aft performing connected stage.

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"My assemblage was hurting," she said. "I want to beryllium Tina Turner. I want to beryllium doing stadium shows erstwhile I’m 70. If my backmost is connected this way correct now, there’s nary way."

Fox News Digital’s Stephanie Giang-Paunon contributed to this report.