Mayim Bialik details ‘explosive’ side effects of ‘nightmare’ GLP-1 drug

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Mayim Bialik branded her acquisition pinch GLP-1 narcotics a “nightmare” successful a candid caller essay.

“I grew up successful nan limelight, pinch my quality scrutinized play from nan clip I starred successful my ain NBC show astatine 14,” nan “Blossom” actress wrote successful a Free Press essay titled “My GLP-1 Nightmare” published Friday.

“I was blissfully unaware of my weight backmost then,” she wrote, describing her younger aforesaid arsenic “naturally lanky and athletic” and being capable to eat “whatever I wanted pinch nary interest for weight gain.”

However, nan former “Jeopardy!” host wrote that arsenic a teen she was “put connected medicine to manage my moods, and weight summation followed maine from there.”

Bialik, now 50, wrote of acquiring a “deep consciousness of shame astir my body” by her 40s, erstwhile she was “still actively moving arsenic an actress.”

“By nan clip societal media arrived — pinch its fixation connected being thinner, much toned, much surgically perfected — that unit tipped into a disordered narration pinch nutrient that I person spent years trying to untangle,” nan “Big Bang Theory” alum wrote.

Mayim Bialik, seen supra successful 2018 astatine nan Critics Choice Awards, elaborate her “nightmare” pinch GLP-1 narcotics successful an effort she wrote for nan Free Press. Getty Images
The actress, seen present successful 2024, said her quality was “scrutinized weekly” from nan property of 14, erstwhile she starred connected “Blossom.” Variety via Getty Images

Early menopause, she divulged, caused an further 20 pounds of weight summation she doesn’t “seem to person nan discipline, motivation, aliases clip to lose.”

“Still, that’s not why I went connected a GLP-1,” nan character continued. “I went connected a weight-loss drug because a expert told maine it mightiness thief easiness symptoms I’ve struggled pinch for fundamentally my full big life.”

Bialik wrote that she was diagnosed pinch Graves’ disease, an autoimmune upset affecting nan thyroid, astatine property 23. Though she was prescribed medication, she didn’t make manner changes — a move she feels mightiness person “very slow made my information worse.”

The neuroscientist was besides diagnosed pinch Sjögren’s syndrome, dysautonomia, connective insubstantial disease, and mast compartment activation syndrome (MCAS) successful later years, and suffered from utmost symptoms of nan conditions, including “crippling depression” and “full-body rashes.”

Bialik shared that abstracted 3 doctors suggested she spell connected a GLP-1 supplier “not because of nan 20 postmenopausal pounds but because nan narcotics person shown committedness successful reducing nan systemic inflammation that drives autoimmune conditions.”

The actress, pictured supra successful 2025, wrote that she began to acquisition weight summation aft she was put connected medicine to negociate her moods successful her teens. Corbis via Getty Images
Bialik, seen supra connected “Jeopardy!,” was later diagnosed pinch respective conditions, including Graves’ disease. ABC via Getty Images

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“Maybe this could beryllium nan magic cure,” she recalled of her mindset astatine nan time.

“GLP-1s person helped group successful superior need. Of that I americium certain,” she wrote. “But cipher talks overmuch astir what happens erstwhile it goes wrong.”

After taking “one changeable of nan lowest dose of a synthetic GLP-1,” Bialik noted that “to opportunity I had an adverse guidance would beryllium somewhat of an understatement.”

She elaborate “explosive, uncontrollable diarrhea,” arsenic good arsenic “sulfur burps truthful convulsive they near maine acrophobic to unfastened my rima successful public,” arsenic immoderate of nan worst side-effects.

“Sneezing attacks each clip I tried to eat aliases portion — which apparently has a name, snatiation,” she continued.

Doctors for Bialik, seen supra successful 2023, suggested she effort a GLP-1 to thief negociate her conditions — not for weight loss. Getty Images
The actress, pictured present successful 2023, elaborate melodramatic broadside effects. Getty Images for Los Angeles LGBT Center

“Cramping. Bloating. Full-body aching, arsenic though I had nan flu” Bialik added. “And an inability to support down moreover mini sips of h2o without sprinting to nan bath pinch yet much explosive diarrhea. More than 3 times, I didn’t make it.”

She shared, “This supplier has a very agelong half-life; my prescribing expert had told maine to expect astatine slightest a week of this, if not more.”

Bialik noted that aft experiencing nan melodramatic broadside effects, her “body made its position clear, and I had learned, aft decades of overriding it, to yet listen.” She yet decided to extremity taking nan GLP-1 and “finally went to spot a gastroenterologist.”

The expert told her GLP-1 narcotics “are highly disruptive to nan assemblage and should not beryllium utilized extracurricular of a specific, regulated group of superior aesculapian reasons — namely, life-compromising obesity and its related wellness consequences” and that she “did not meet that bar.”

Bialik, seen present successful “Night Court” pinch John Larroquette successful 2025, yet decided to extremity nan GLP-1. Nicole Weingart/NBC via Getty Images
A gastroenterologist later confirmed to Bialik, seen present connected “The Big Bang Theory” successful 2019, nan narcotics “are highly disruptive to nan body” and she decided to extremity taking them. CBS via Getty Images

Bialik recalled leaving nan specialist’s agency “feeling validated,” noting that “a existent expert confirming I was not a freak, that nan medicine really had done this to maine — and trepidatious that location was much to woody pinch successful nan coming weeks.”

She concluded nan effort pinch an ironic representation of her appointment.

“On my measurement out, I caught a glimpse of my reflection, and I did not recoil,” nan “Call Me Kat” character recounted.

“I did not spot nether my first chin that 2nd chin connected which I had been fixating for months — because it wasn’t there. My cheekbones were visible. I gazed for a moment, flashed a Mona Lisa smile, and headed to nan parking lot, stopping concisely to hike up my skirt, which had started to sag astatine my hips ever truthful slightly.”

Bialik isn’t nan first personage to speak retired astir the antagonistic effects of GLP-1s — Bunnie XO, Brianna “Chickenfry” LaPaglia and Kris Jenner person each shared cautionary tales successful caller years astir nan progressively celebrated weight-loss medications.

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