Joe Manganiello details ‘brutal side effects’ of secret health battle: ‘I suffered in silence’

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Joe Manganiello revealed much astir his alarming wellness battle that he kept concealed for almost a decade.

The “True Blood” alum, in an Instagram video Wednesday, said he “suffered successful soundlessness battling a deadly enigma illness” he only told a mini circle of loved ones about. He recalled seeing “the champion doctors successful nan world,” whom he said couldn’t fig retired what started his condition.

“All their attempts to dainty it pinch high-powered biologic narcotics only exacerbated my symptoms and past unlocked a big of sadistic broadside effects that winded up plaguing maine for years,” Manganiello said.

“And past successful attempts to bargain myself time,” he continued, “I underwent very superior operations and procedures that mutilated parts of my assemblage and near maine truthful anemic astatine times that I couldn’t guidelines up aliases walk.”

Joe Manganiello revealed much astir his concealed unwellness he battled for almost a decade successful an Instagram video Wednesday (a screenshot of which is seen above). Instagram/Joe Manganiello
The “True Blood” alum (seen present successful nan societal media post) said doctors couldn’t fig retired what started his unwellness but prescribed him “high-powered biologic drugs” that gave him “brutal broadside effects.” Instagram/Joe Manganiello

The “Magic Mike” alum, 49, besides shared that he spent months “heavily medicated while dealing pinch excruciating bouts of chronic pain.” He noted that his upcoming memoir, “Bloodlines,” retired Oct. 13, documents his 10-year hunt for answers arsenic good arsenic a heavy dive into his family’s history.

“Maybe what happened to maine wasn’t random,” he says. “And that successful bid to heal, my mind, my body, my tone each had to align and I needed to go unfastened to immoderate really extremist and unorthodox techniques and ideas that dishonesty beyond nan boundaries of occidental medicine.”

Manganiello shared a supportive connection for those who mightiness beryllium going done a akin situation.

“If you’re retired location and you’re suffering, there’s hope,” he said.

Manganiello — pictured present successful March 2025 — said he dealt pinch nan broadside effects for years and besides underwent operations that “mutilated” parts of his body. Getty Images
His upcoming memoir, “Bloodlines” (the screen of which is seen here), documents his unwellness and nan replacement treatments he sought. Simon & Schuster

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In a synopsis for “Bloodlines,” Manganiello shares that he dealt pinch “a cascade of autoimmune-related illnesses” that attacked his thyroid, digestive system, skin, lungs and eyes.

Over nan people of 7 years, he revealed that he dealt pinch “chronic pain, a life-saving organ amputation, existential situation and a prolonged conflict for endurance that near doctors pinch fewer answers and nary clear explanation.”

Manganiello ended up turning to replacement medicine for illustration “shamans, pagan rituals, ancient myths, long-lost family records and nan rebirth of his ain spirituality” to thief dainty his illness.

The erstwhile “Deal aliases No Deal Island” big besides did intensive investigation into his ain family genealogy and discovered ancestors who survived nan Armenian genocide and others who lived pinch chronic illness.

Manganiello (pictured present successful a societal media post) has not yet revealed nan years he suffered from his illness. Instagram/joemanganiello
The character announced his engagement to character Caitlin O’Connor past October. They’re pictured present successful April 2025. WireImage

Manganiello has not revealed nan years his wellness conflict occurred.

He was antecedently joined to character Sofía Vergara, 53, from 2015 to 2024. The “Modern Family” alum said successful January 2024 that nan 2 divided because she didn’t want to person kids pinch him and beryllium “an aged mom.”

“I consciousness it’s not adjacent to nan baby,” she told El País.

Vergara is already a mom to her son, 34-year-old Manolo, whom she shares pinch ex-husband Joe Gonzalez.

Manganiello is now engaged to character Caitlin O’Connor, 36, which nan mates announced past October.

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