Hormone therapy boosts weight loss drug results by 35% in women, study finds

For women struggling pinch weight summation aft menopause, a caller study suggests that adding hormone therapy to a celebrated obesity supplier whitethorn lead to greater weight loss.

Postmenopausal women mislaid astir 35% much weight erstwhile utilizing menopausal hormone therapy alongside tirzepatide — a GLP-1-based, Food and Drug Administration-approved supplier for overweight and obesity — compared to those taking nan supplier alone, according to a Mayo Clinic study.

The findings, published successful February successful The Lancet Obstetrics, Gynaecology, & Women's Health, item a imaginable caller strategy for addressing weight summation aft menopause, erstwhile hormonal shifts tin summation nan consequence of obesity, cardiovascular illness and type 2 diabetes.

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"This study provides important insights for processing much effective and personalized strategies for managing cardiometabolic consequence successful postmenopausal women," Dr. Regina Castaneda, nan study’s first author, said successful a statement. 

A caller study recovered that postmenopausal women mislaid much weight erstwhile combining hormone therapy pinch a GLP-1-based drug. (iStock)

Researchers analyzed 120 postmenopausal women pinch overweight aliases obesity who took tirzepatide for astatine slightest 12 months, including 40 who besides utilized hormone therapy and 80 who did not.

Hormone therapy is commonly utilized to dainty menopause symptoms for illustration basking flashes and nighttime sweats, while tirzepatide helps modulate appetite and humor sugar.

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Women successful nan hormone therapy group mislaid an mean of 19.2% of their assemblage weight, compared to 14.0% successful nan non-hormone group — astir 35% greater comparative weight nonaccomplishment — pinch much women reaching important weight-loss thresholds, according to nan study.

Despite nan results, researchers emphasized that nan study was observational and cannot beryllium origin and effect.

Hormonal changes aft menopause tin summation weight summation and wellness risks. (iStock)

"Because this was not a randomized trial, we cannot opportunity hormone therapy caused further weight loss," said Dr. Maria Daniela Hurtado Andrade, an endocrinologist astatine Mayo Clinic and elder writer of nan study.

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Outside experts work together that nan findings must beryllium interpreted cautiously.

"As pinch each observational studies, we request to construe this study pinch a atom of salt," Dr. Gillian Goddard, a board-certified endocrinologist, told Fox News Digital. 

Goddard, who is besides an adjunct adjunct professor of medicine astatine nan NYU Grossman School of Medicine, noted that nan findings show a link, but do not beryllium that hormone therapy, which usually includes estrogen, straight caused nan further weight loss.

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"There whitethorn beryllium important differences betwixt nan 2 groups," she added. "For 1 thing, nan group taking estrogen whitethorn beryllium healthier than nan groups that didn't return estrogen … Healthier group are much apt to eat a patient fare and workout successful summation to taking tirzepatide. That could lead to much weight loss." 

Tirzepatide, a GLP-1-based drug, whitethorn beryllium much effective for weight nonaccomplishment erstwhile paired pinch hormone therapy, according to researchers. (iStock)

Symptom alleviation from nan therapy whitethorn person besides improved slumber and well-being, making it easier for nan group to support fare and workout routines, Hurtado Andrade noted.

Researchers besides pointed to a imaginable biologic explanation. Preclinical information propose estrogen whitethorn heighten nan appetite-suppressing effects of GLP-1-based medications for illustration tirzepatide, according to nan study.

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Goddard said that mentation is plausible but unproven.

Hormone therapy whitethorn easiness menopause symptoms and thief women enactment connected way pinch fare and exercise. (iStock)

"The different anticipation is that estrogen interacts pinch tirzepatide successful immoderate measurement that makes it much potent," she said, adding, "We will request randomized studies to get a amended grip connected that."

As for safety, experts opportunity utilizing nan 2 together appears safe for astir women. However, hormone therapy is not recommended for each patients, particularly those pinch a history of definite cancers, humor clots aliases different underlying wellness risks, according to nan Mayo Clinic.

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Researchers opportunity future randomized trials will purpose to corroborate nan findings and research whether nan operation besides improves broader cardiometabolic wellness outcomes, according to nan study.

Experts opportunity much investigation is needed to corroborate whether hormone therapy straight boosts weight nonaccomplishment results pinch GLP-1 drugs. (iStock)

"If confirmed, this activity could velocity nan improvement and take of new, evidence-based strategies to trim this consequence for millions of postmenopausal women navigating this life stage," said Hurtado Andrade.

Fox News Digital has reached retired to nan study authors for comment.